The role of CAF derived exosomal microRNAs in the tumour microenvironment of melanoma

Exosomes play a crucial role in the crosstalk between cancer associated fibroblasts (CAFs) and cells, contributing to carcinogenesis tumour microenvironment. Recent studies have revealed that CAFs, normal cells all secrete exosomes contain miRNA, establishing cell-cell communication network within For example, miRNA dysregulation melanoma has been shown promote CAF activation via induction of epithelial-mesenchymal transition (EMT), which turn alters secretory phenotype CAFs stroma. This review assesses roles exosomal miRNAs formation how exosome-mediated feedback signalling lead progression metastasis. Moreover, efforts exploit miRNA-mediated their microenvironment, potential as prognostic biomarkers or novel therapeutic targets will also be considered.